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Which statement describes the role of ligase in DNA repair?

Answer and explanation

Correct answer: It seals a nick in a damaged DNA strand

During DNA repair, after a damaged section is removed and replacement nucleotides are added, a small break called a nick may remain in the sugar-phosphate backbone. DNA ligase seals this nick by forming a phosphodiester bond, restoring continuity of the DNA strand. Removal of a damaged base is mainly performed by a DNA glycosylase, not ligase. Exam tip: remember ligase as the enzyme that ‘joins DNA breaks’.

Related tags

Dna RepairDna LigaseNick SealingPhosphodiester BondBiotechnologyLigase EnzymesPrinciples Of BiotechnologyClass 11 Mcq

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