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Which enzyme closes a nick in the DNA backbone?

Answer and explanation

Correct answer: DNA ligase

DNA ligase seals a nick in the sugar-phosphate backbone of DNA by forming a phosphodiester bond. DNA polymerase synthesises new DNA, but DNA ligase performs the final sealing of a nick. Exam tip: Choose DNA ligase when the question mentions joining DNA ends or sealing a nick.

Related tags

Dna LigaseDna BackboneNick SealingPhosphodiester BondRecombinant DnaLigase EnzymesPrinciples Of BiotechnologyBiotechnology

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