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DNA ligase directly helps in repair of which type of DNA damage?

Answer and explanation

Correct answer: single-strand nick

DNA ligase seals a single-strand nick in the sugar-phosphate backbone of DNA by forming a phosphodiester bond. Thus, it directly restores continuity of the DNA strand. Complete chromosome loss cannot be repaired simply by the action of ligase. Exam tip: remember that ligase joins broken DNA ends or seals nicks.

Related tags

Dna LigaseDna RepairSingle-Strand NickPhosphodiester BondBiotechnology EnzymesLigase EnzymesPrinciples Of BiotechnologyBiotechnology

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