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Why can DNA ligase be called molecular glue?

Answer and explanation

Correct answer: It joins DNA pieces

The term molecular glue is an analogy based on function, not on a sticky physical substance. DNA ligase brings neighbouring DNA ends into a suitable arrangement and catalyses covalent phosphodiester-bond formation between them. This permanently joins DNA fragments or closes a nick in the backbone, much as glue joins two pieces of material. Therefore option A is correct. Restriction enzymes, rather than ligase, cut DNA at particular sites. RNA polymerase produces RNA from a DNA template, and no normal ligase reaction converts DNA into sugar. The analogy is useful because ligase connects pre-existing molecular pieces without creating an entirely new strand from individual nucleotides.

Related tags

Molecular GlueDna LigaseDna JoiningLigase EnzymesPrinciples Of BiotechnologyBiotechnologyClass 11 Mcq

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