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Why is low oxygen solubility a challenge in bioprocessing?

Answer and explanation

Correct answer: It can be difficult to supply enough oxygen to aerobic cells

The governing concept is oxygen transfer in an aerobic bioprocess. Oxygen has limited solubility in aqueous culture medium, so the dissolved oxygen available to cells can fall below their metabolic requirement. When oxygen becomes limiting, cell growth, respiration, and product formation may decrease. Agitation and aeration increase gas–liquid contact and help replenish dissolved oxygen, while sensors can monitor its concentration. Therefore, option A is correct because supplying enough oxygen to aerobic cells may be difficult. Option B concerns physical state, option C is unrelated to oxygen transfer, and option D is not a consequence of oxygen solubility.

Related tags

Oxygen SolubilityAerobic CultureAerationBioprocess EngineeringPrinciples Of BiotechnologyBiotechnologyClass 11 Mcq

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